Contact us for free consultation and advice — Phone: 1 877 842 4827 — Fax: 1 855 897 2528 — E-mail: info@accu-metrics.com Contact us for free consultation and advice
Phone: 1 877 842 4827 — Fax: 1 855 897 2528
E-mail: info@accu-metrics.com




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Genetic Trait Tests

Dogs

Each Genetic Test is $36

2 or more genetic tests is $30 each (e.g. Color trait + Factor VII Deficiency)

Color traits

Two pigments provide the basis for hair color in mammals 1) eumelanin (black) and 2) pheomelanin (red or yellow). In dogs the gene responsible for the production of these pigments is known as Melanocortin 1 Receptor (MC1R), which is also known as Extension (E).
There are a number of other genes that modify these pigments to produce the variety of coat colors found in the domesticated dog.
The gene Tyrosinase-Related Protein 1 (TYRP1), which is also known as the Brown (B) gene, dilutes the black pigment to become brown but does not impact on the red pigment.
Other genes involved in dog coat color include ASIP or Agouti (A) that functions to organizes the distribution of black and red pigments.
The gene Beta-defensin (CBD-103) (K) is responsible for dominant black.
Dilute (MLPH) (D) dilutes black and red pigments.
The (S) test - white/parti/piebald/landseer/flowered/spotted

Non-color traits

Coat Length
While it is not a color trait, the length of a dog's coat is of interest to many.
Furnishings
Furnishings refer to the variation of longer facial hair seen in all wire haired breeds as well as some others.
Curly
A mutation responsible for curly coat in dogs has recently been identified in the KRT71 gene.

Genetic Disease Tests

cord1 - PRA
Cone-Rod Dystrophy 1 - Progressive Renal Atrophy (cord1 - PRA) is an inherited disease of the eye that affects the cone and rod cells that make up the dog's retina and often leading to blindness.

CNM-Centronuclear Myopathy
Centronuclear myopathy in Labrador Retrievers is a recessively inherited muscular disease. This disease was previously known as Labrador muscular myopathy.

Canine copper toxicosis ("CT") is an autosomal recessive disorder of copper accumulation which results in severe liver disease in several dogbreeds. Unless specific anti-copper treatment is instituted, most affected dogs die at three to seven years of age. CT is, in particular, a severe problem in Bedlington Terriers.

Cyclic Neutropenia
Canine Cyclic Neutropenia Canine cyclic neutropenia, also known as ‘gray collie syndrome’ (GCS), is an autosomal recessive disease. Both parents must carry the abnormal gene for the offspring to be affected.

Cystinuria
Cystinuria in the Newfoundland dog is indicated by the presence of cystine stones in the kidney, bladder or ureter. Failure by the kidneys to reabsorb amino acids results in the formation of these stones.

Dilated Cardiomyopathy
This disease of the heart can result in sudden death of relatively young dogs

Factor VII Deficiency
Factor VII deficiency is a generally mild bleeding disorder.

Greyhound Polyneuropathy
Greyhound Polyneuropathy is a severe and progressive disease which is found in show lines of the Greyhound breed.

Hemophilia B
Hemophilia B is often a severe bleeding disorder caused by a deficiency of coagulation factor IX resulting in a severely affected blood clotting process.

Hereditary Cataract

There are several types of inherited cataract in the dog which vary in both their appearance and age of onset. The majority of these are inherited as autosomal recessive traits, but some are inherited as dominant or perhaps polygenic trait

Hyperuricosuria
Inherited hyperuricosuria causes dogs to produce urine with very high levels of uric acid. This can lead to bladder stones, and less frequently kidney stones.

HHereditary Nephritis
Hereditary nephritis in the Samoyed is a dominant, X-linked disease that affects young male dogs more severely than females

NCL-Neuronal Ceroid Lipofuscinosis
A young-adult onset NCL occurs in American Bulldogs and a mutation in the cathepsin D gene (CSTD) responsible for NCL in this breed has been identified. (Awano et al 2006)

NE-Neonatal Encephalopathy
Neonatal encephalopathy is a recessive developmental brain disease.

PDP1
Pyruvate Dehydrogenase Phosphatase 1 deficiency is characterized by exercise intolerance and postexercised collapse.

PFK-Phosphofructokinase deficiency
Canine Phosphofructokinase (PFK) deficiency is an autosomal recessive genetic disease which prevents the metabolism of glucose into available energy resulting in exercise intolerance and muscle disease in Cocker Spaniels.

PK-Pyruvate Kinase deficiency
Pyruvate kinase (PK) deficiency in Basenji dogs is an inherited lack of an enzyme (pyruvate kinase) in the red blood cells of an affected animal.

PRA-Progressive Retinal Atrophy
Irish setter progressive retinal atrophy (PRA) is an inherited disease that leads to blindness in affected dogs. It is inherited in a simple autosomal recessive fashion

PLL-Primary Lens Luxation
PLL is an inherited condition that affects many breeds of dog. It is characterized my movement of the lens away from its normal location in the eye.

RCND
Renal Cystadenocarcinoma Nodular Dermatofibrosis (RCND) is a naturally occurring canine kidney cancer syndrome that was originally described in German Shepherd dogs.

vWD
von Willebrand’s disease has been identified in a wide range of canine breeds, and is the most common of the inherited bleeding disorders. As with humans, there are three classifications of this disease, Types I, II, and III. These are based on the concentration and nature of plasma vWF.

Type I vWD
Viaguard exclusively is offering the mutation that causes Type I von Willebrand's Disease (vWD) and the offering of a DNA test to detect vWD in all breeds.

Type II vWD
Type II vWD is characterized by abnormal vWF, as opposed to low levels of normal vWF. This type is not as common as Type I, but a mutation causing it has been identified in some pointing breeds and Deutch Drahthaar.

Type III vWD
Canine von Willebrand's disease (vWD) in Scotties is an autosomal recessive genetic disease with a gene frequency estimated to be 15% of the Scottie population.